Cyto-Histological Correlation of Thyroid Lesions with Estrogen and Progesterone Receptor Status on Neoplastic Lesions
Published: June 1, 2012 | DOI: https://doi.org/10.7860/JCDR/2012/.2200
Shilpi Bhargava,
Rani Bansal,
Poonam Elhence,
Sanjay Pandey,
Natasha Makkar
1. MD(3rd yr.), Subharti Medical College, Meerut, India.
2. Professor & Head, Subharti Medical College, Meerut, India.
3. Associate Professor, Subharti Medical College, Meerut, India.
4. Associate Professor, Subharti Medical College, Meerut, India.
5. MD (3rd yr.), Subharti Medical College, Meerut, India.
Correspondence
Dr. Shilpi Bhargava
Department of Pathology.
Subharti Medical College, Meerut, India -250003.
Phone: 09760062926
E-mail: drshilpi222@gmail.com
Introduction: Thyroid nodules are common clinical findings, they are more common in women and this incidence increases with age, a history of radiation exposure and with a diet which contains goitrogenic material. Fine needle aspiration cytology (FNAC) is an established technique for the investigation of thyroid nodules. The aim of the present study was to establish a correlation between the cytological features and the histomorphology of various neoplastic and non-neoplastic lesions. Secondly, we aimed to analyze the oestrogen receptor (ER) and the progesterone receptor (PR) status in malignant thyroid tumours.
Materials and Methods: The FNAC of 448 thyroid lesions was performed, with the histological correlation being available in 122 cases, over a period of 5 years. Immunohistochemistry was performed on the neoplastic lesions by the peroxidase- anti-peroxidase technique by using a mouse monoclonal antibody clone.
Results: A cyto-histological discrepancy was noted in 8 cases. On considering histological diagnosis as the gold standard, the overall accuracy was found to be 92.9%.The male:female ratio was 1:7.2 and the maximum number of cases belonged to the nodular colloid goiter category (82.36%). An immunohistochemical analysis for ER and PR was performed on 11 cases of thyroid malignancy, with a single case of papillary carcinoma showing focal nuclear positivity for the progesterone receptors.
Conclusion: The focal nuclear PR positivity which was seen in a single case cannot predict the biological behaviour of the tumour and thus, the use of anti-oestrogenic drugs like tamoxifen is questionable for the management of thyroid cancer. This needs to be confirmed further by taking up similar studies with a larger number of cases.
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